The average bus between 16th Street Mission Station and Palo Alto takes 2h 59m and the fastest bus takes 2h 19m. The bus runs at least 3 times per hour from 16th Street Mission Station to Palo Alto. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 20 minutes between 16th Street Mission Station and Palo Alto. The earliest departure is at 5:45 AM in the morning, and the last departure from 16th Street Mission Station is at 6:09 PM which arrives into Palo Alto at 8:43 PM. All services require a transfer, and take on average 2h 59m. The schedules shown below are for the next available departures.

2h 34m • 1 change

2h 39m • 1 change

2h 39m • 1 change

2h 39m • 1 change
Want to know about travelling from 16th Street Mission Station to Palo Alto? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from 16th Street Mission Station to Palo Alto. However, there are services departing from 16th Street Mission Station station and arriving at Palo Alto station via Palo Alto Transit Ctr-Bay 1. The journey, including transfers, takes approximately 2h 59m.
16th Street Mission Station to Palo Alto bus services, operated by San Francisco Municipal Transportation Agency, depart from Daly City BART-Bay 1 station.
16th Street Mission Station to Palo Alto bus services, operated by San Francisco Municipal Transportation Agency, arrive at Palo Alto Transit Ctr-Bay 1 station.
The distance between 16th Street Mission Station and Palo Alto is 43.4 km. The road distance is 55 km.
SamTrans operates a bus from Daly City BART-Bay 1 to Palo Alto Transit Ctr-Bay 1 every 15 minutes. Tickets cost $2–4 and the journey takes 2h 15m.