The average bus between Amsterdam and Mainz-Drais takes 10h 26m and the fastest bus takes 7h 54m. The bus service runs several times per day from Amsterdam to Mainz-Drais. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Amsterdam and Mainz-Drais. The earliest departure is at 9:50 AM in the morning, and the last departure from Amsterdam is at 10:45 PM which arrives into Mainz-Drais at 8:41 AM. All services require a transfer at Frankfurt central train station and take an average of 10h 26m. The schedules shown below are for the next available departures.


10h 4m • 2 changes

12h 35m • 2 changesArrives next day


10h 9m • 2 changesArrives next day


10h 9m • 2 changes

10h 4m • 2 changes

12h 35m • 2 changesArrives next day


10h 9m • 2 changesArrives next day


10h 9m • 2 changes

10h 4m • 2 changes

11h 56m • 2 changesArrives next day


7h 54m • 2 changes

10h 4m • 2 changes

12h 35m • 2 changesArrives next day


7h 54m • 2 changesWant to know about travelling from Amsterdam to Mainz-Drais? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Amsterdam to Mainz-Drais. However, there are services departing from Amsterdam station and arriving at Mainz-Drais station via Frankfurt central train station station. The journey, including transfers, takes approximately 10h 26m.
Amsterdam to Mainz-Drais bus services, operated by FlixBus, depart from Amsterdam Sloterdijk station.
Amsterdam to Mainz-Drais bus services, operated by FlixBus, arrive at Frankfurt central train station.
The distance between Amsterdam and Mainz-Drais is 352.2 km. The road distance is 494 km.
FlixBus operates a bus from Amsterdam Sloterdijk to Frankfurt central train station every 3 hours. Tickets cost €30–55 and the journey takes 6h 5m.