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Anaheim to La Mesa buses

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Trip Overview

The average bus between Anaheim and La Mesa takes 4h 46m and the fastest bus takes 3h 2m. The bus service runs several times per day from Anaheim to La Mesa. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 46m
Duration
106 mi
Distance
$35
Average price
3 times a day
Frequency

Anaheim to La Mesa bus times

Buses run 3 times a day between Anaheim and La Mesa. The earliest departure is at 10:15 AM in the morning, and the last departure from Anaheim is at 9:40 PM which arrives into La Mesa at 6:51 AM. All services require a transfer at San Diego and take an average of 4h 46m. The schedules shown below are for the next available departures.

Departing Monday, November 9, 2026

  •  → 

    Flixbus USASan Diego Metro TransitSan Diego Metro Transit3h 2m • 2 changes
  •  → 

    Flixbus USASan Diego Metro TransitSan Diego Metro Transit3h 20m • 2 changes
  •  → 

    Greyhound USASan Diego Metro TransitSan Diego Metro Transit3h 14m • 2 changes
  •  → 

    Arrives next day

    Greyhound USASan Diego Metro TransitSan Diego Metro Transit9h 11m • 2 changes

Departing Tuesday, November 10, 2026

  •  → 

    Flixbus USASan Diego Metro TransitSan Diego Metro Transit3h 2m • 2 changes
  •  → 

    Flixbus USASan Diego Metro TransitSan Diego Metro Transit3h 20m • 2 changes
  •  → 

    Greyhound USASan Diego Metro TransitSan Diego Metro Transit3h 14m • 2 changes
  •  → 

    Arrives next day

    Greyhound USASan Diego Metro TransitSan Diego Metro Transit9h 11m • 2 changes

Departing Wednesday, November 11, 2026

  •  → 

    Flixbus USASan Diego Metro TransitSan Diego Metro Transit3h 2m • 2 changes
  •  → 

    Greyhound USASan Diego Metro TransitSan Diego Metro Transit3h 14m • 2 changes
  •  → 

    Arrives next day

    Greyhound USASan Diego Metro TransitSan Diego Metro Transit9h 11m • 2 changes

Departing Thursday, November 12, 2026

  •  → 

    Flixbus USASan Diego Metro TransitSan Diego Metro Transit3h 2m • 2 changes
  •  → 

    Flixbus USASan Diego Metro TransitSan Diego Metro Transit3h 20m • 2 changes
  •  → 

    Greyhound USASan Diego Metro TransitSan Diego Metro Transit3h 14m • 2 changes
  •  → 

    Arrives next day

    Greyhound USASan Diego Metro TransitSan Diego Metro Transit9h 11m • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Flixbus USASan Diego Metro TransitSan Diego Metro Transit3h 2m • 2 changes
  •  → 

    Flixbus USASan Diego Metro TransitSan Diego Metro Transit3h 20m • 2 changes
  •  → 

    Greyhound USASan Diego Metro TransitSan Diego Metro Transit3h 14m • 2 changes

Frequently asked questions

Want to know about travelling from Anaheim to La Mesa? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Anaheim to La Mesa.ExpandLaunch map view
  • Distance: 106.2 mi
  • Duration: 4h 46m

What companies run services between Anaheim, CA, USA and La Mesa, CA, USA?

Greyhound Mexico operates a bus from Anaheim to San Diego twice daily. Tickets cost $17–27 and the journey takes 2h 10m.

Operators