The average bus between Anaheim and Otay Mesa Port of Entry takes 4h 39m and the fastest bus takes 3h 10m. The bus service runs several times per day from Anaheim to Otay Mesa Port of Entry. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Anaheim and Otay Mesa Port of Entry. The earliest departure is at 9:40 AM in the morning, and the last departure from Anaheim is at 9:40 PM which arrives into Otay Mesa Port of Entry at 4:35 AM. All services require a transfer at San Ysidro Transit Center and take an average of 4h 39m. The schedules shown below are for the next available departures.


3h 45m • 2 changes


3h 10m • 2 changes
Arrives next day


6h 55m • 2 changes


3h 40m • 2 changes


3h 10m • 2 changes
Arrives next day


7h 9m • 2 changes


3h 39m • 2 changes


3h 24m • 2 changes
Arrives next day


7h 9m • 2 changes


3h 39m • 2 changes


3h 24m • 2 changes
Arrives next day


6h 55m • 2 changes


3h 40m • 2 changes


3h 10m • 2 changes
Arrives next day


6h 55m • 2 changes
Want to know about travelling from Anaheim to Otay Mesa Port of Entry? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Anaheim to Otay Mesa Port of Entry. However, there are services departing from Anaheim station and arriving at Otay Mesa Port of Entry station via San Ysidro Bus Terminal. The journey, including transfers, takes approximately 4h 39m.
Anaheim to Otay Mesa Port of Entry bus services, operated by Greyhound USA, depart from Anaheim Regional Transportation Intermodal Center station.
Anaheim to Otay Mesa Port of Entry bus services, operated by Greyhound USA, arrive at San Ysidro Bus Terminal station.
The distance between Anaheim and Otay Mesa Port of Entry is 169.3 km. The road distance is 197 km.
Greyhound USA operates a bus from Anaheim Regional Transportation Intermodal Center to San Ysidro Bus Terminal twice daily. Tickets cost $16–35 and the journey takes 2h 40m. Flixbus USA also services this route twice daily.