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Anna Maria Island to Florida Keys buses

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Trip Overview

The average bus between Anna Maria Island and Florida Keys takes 25h 35m and the fastest bus takes 22h 20m. The bus runs, on average, 6 times per week from Anna Maria Island to Florida Keys. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

25h 35m
Duration
414 mi
Distance
$80
Average price
6 times a week
Frequency

Anna Maria Island to Florida Keys bus times

Buses run 6 times a week between Anna Maria Island and Florida Keys. The earliest departure is at 12:25 PM in the afternoon, and the last departure from Anna Maria Island is at 7:55 PM which arrives into Florida Keys at 12:15 PM. All services require a transfer at Downtown Station and take an average of 25h 35m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Manatee County Area TransitSarasota County Area TransitSarasota County Area TransitFlixbus USAGreyhound USAKey West Transit23h 50m • 5 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Manatee County Area TransitSarasota County Area TransitSarasota County Area TransitFlixbus USAGreyhound USAKey West Transit22h 20m • 5 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives next day

    Manatee County Area TransitSarasota County Area TransitSarasota County Area TransitFlixbus USAGreyhound USAKey West Transit22h 20m • 5 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives next day

    Manatee County Area TransitSarasota County Area TransitSarasota County Area TransitFlixbus USAGreyhound USAKey West Transit22h 20m • 5 changes
  •  → 

    Arrives +2 days

    Manatee County Area TransitSarasota County Area TransitSarasota County Area TransitFlixbus USAGreyhound USAKey West Transit40h 20m • 5 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Manatee County Area TransitSarasota County Area TransitSarasota County Area TransitFlixbus USAGreyhound USAKey West Transit22h 20m • 5 changes

Frequently asked questions

Want to know about travelling from Anna Maria Island to Florida Keys? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Anna Maria Island to Florida Keys.ExpandLaunch map view
  • Distance: 413.9 mi
  • Duration: 25h 35m

What companies run services between Anna Maria Island, FL, USA and Florida Keys, FL, USA?

You can take a bus from Gulf Dr/42Nd St to Florida Keys via Downtown Station, 13Th St W @ 6Th Ave W Ns, Downtown Transfer Station, Cattlemen Transit Station, Sarasota Cattlemen Transfer Center, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 14h 8m.

Operators