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Annapolis to Port Saint Lucie buses

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Trip Overview

The bus between Annapolis and Port Saint Lucie takes 37h 52m. The bus runs, on average, once a week from Annapolis to Port Saint Lucie. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

37h 52m
Duration
1,114 mi
Distance
$216
Average price
Once a week
Frequency

Annapolis to Port Saint Lucie bus times

Buses run once a week between Annapolis and Port Saint Lucie. The service departs Annapolis at 5:00 PM in the evening, which arrives into Port Saint Lucie at 06:52:00. All services require a transfer at Washington Union Station and take an average of 37h 52m. The schedules shown below are for the next available departures.

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Flixbus USAFlixbus USAFlixbus USAArea Regional Transit St Lucie37h 52m • 3 changes

Frequently asked questions

Want to know about travelling from Annapolis to Port Saint Lucie? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Annapolis to Port Saint Lucie.ExpandLaunch map view
  • Distance: 1,114.1 mi
  • Duration: 37h 52m

What companies run services between Annapolis, MD, USA and Port Saint Lucie, FL, USA?

You can take a bus from Annapolis to SW PSL Blvd & SE Bayshore Blvd via Washington Union Station, West Palm Beach Bus Station, WPB ITC at BAY D, and SW Gatlin Blvd & SW Brescia St in around 24h 34m.

Operators