The average bus between Anne Frankhuis and Brussels takes 3h 40m and the fastest bus takes 3h 4m. There is a bus service every few hours from Anne Frankhuis to Brussels. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run hourly between Anne Frankhuis and Brussels. The earliest departure is at 12:25 AM at night, and the last departure from Anne Frankhuis is at 10:12 PM which arrives into Brussels at 2:35 AM. All services require a transfer at Amsterdam, Buiten Brouwersstraat and take an average of 3h 40m. The schedules shown below are for the next available departures.

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3h 30m • 1 changeWant to know about travelling from Anne Frankhuis to Brussels? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Anne Frankhuis to Brussels. However, there are services departing from Anne Frankhuis station and arriving at Brussels station via Brussels-North train station station. The journey, including transfers, takes approximately 3h 40m.
Anne Frankhuis to Brussels bus services, operated by GVB, depart from Amsterdam Sloterdijk station.
Anne Frankhuis to Brussels bus services, operated by GVB, arrive at Brussels-North train station.
The distance between Anne Frankhuis and Brussels is 173.5 km. The road distance is 212 km.
FlixBus operates a bus from Amsterdam Sloterdijk to Brussels-North train station hourly. Tickets cost €17–26 and the journey takes 2h 45m.