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Ascoli Piceno to Isernia buses

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Trip Overview

The average bus between Ascoli Piceno and Isernia takes 7h 13m and the fastest bus takes 5h 35m. The bus service runs several times per day from Ascoli Piceno to Isernia. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

7h 13m
Duration
367 km
Distance
€30
Average price
3 times a day
Frequency

Ascoli Piceno to Isernia bus times

Buses run 3 times a day between Ascoli Piceno and Isernia. The earliest departure is at 5:35 AM in the morning, and the last departure from Ascoli Piceno is at 5:35 PM which arrives into Isernia at 11:10 PM. All services require a transfer, and take on average 7h 13m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Start SPAATM Azienda di Trasporti Molisana S.p.A.7h 50m • 1 change
  •  → 

    Start SPAFlixBus7h 45m • 1 change
  •  → 

    Start SPAATM Azienda di Trasporti Molisana S.p.A.6h 5m • 1 change

Departing Thursday, November 12, 2026

  •  → 

    Start SPAATM Azienda di Trasporti Molisana S.p.A.7h 50m • 1 change
  •  → 

    Start SPAFlixBus7h 45m • 1 change
  •  → 

    Start SPAATM Azienda di Trasporti Molisana S.p.A.6h 5m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Start SPAATM Azienda di Trasporti Molisana S.p.A.7h 50m • 1 change
  •  → 

    Start SPAFlixBus7h 45m • 1 change
  •  → 

    Start SPAATM Azienda di Trasporti Molisana S.p.A.6h 5m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    Start SPAATM Azienda di Trasporti Molisana S.p.A.7h 50m • 1 change
  •  → 

    Start SPAFlixBus7h 45m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Start SPAFlixBus7h 45m • 1 change
  •  → 

    Start SPAATM Azienda di Trasporti Molisana S.p.A.5h 35m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Start SPAATM Azienda di Trasporti Molisana S.p.A.7h 50m • 1 change
  •  → 

    Start SPAFlixBus7h 45m • 1 change
  •  → 

    Start SPAATM Azienda di Trasporti Molisana S.p.A.6h 5m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    Start SPAATM Azienda di Trasporti Molisana S.p.A.7h 50m • 1 change
  •  → 

    Start SPAFlixBus7h 45m • 1 change
  •  → 

    Start SPAATM Azienda di Trasporti Molisana S.p.A.6h 5m • 1 change

Frequently asked questions

Want to know about travelling from Ascoli Piceno to Isernia? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Ascoli Piceno to Isernia.ExpandLaunch map view
  • Distance: 366.5 km
  • Duration: 7h 13m

What companies run services between Ascoli Piceno, Italy and Isernia, Italy?

You can take a bus from Ascoli Piceno to Isernia via Roma, Autostazione Tiburtina in around 6h 20m.

Operators