Avignon Centre to Lyon Buses

Avignon Centre to Lyon buses

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Trip Overview

The average bus between Avignon Centre and Lyon takes 3h 34m and the fastest bus takes 2h 56m. The bus service runs several times per day from Avignon Centre to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 34m
Duration: 239 km
Distance: €23
Average price: Every 3 hours
Frequency

Bus

best

Take the bus from Avignon to Lyonbus FlixBus N1135 / ...

3h 59m

€16–29

Avignon Centre to Lyon bus times

Buses run every 3 hours between Avignon Centre and Lyon. The earliest departure is at 12:00 AM at night, and the last departure from Avignon Centre is at 11:42 PM which arrives into Lyon at 12:55 AM. All services require a transfer at Le Lac and take an average of 3h 34m. The schedules shown below are for the next available departures.

Departing Wednesday, October 21, 2026

9:53 AM → 1:15 PM
3h 22m • 1 change
11:20 AM → 3:05 PM
3h 45m • 1 change
1:30 PM → 5:10 PM
3h 40m • 1 change
6:31 PM → 9:45 PM
3h 14m • 1 change
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Departing Thursday, October 22, 2026

7:57 AM → 11:50 AM
3h 53m • 1 change
9:53 AM → 1:15 PM
3h 22m • 1 change
11:20 AM → 3:05 PM
3h 45m • 1 change
1:30 PM → 5:10 PM
3h 40m • 1 change
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Departing Friday, October 23, 2026

7:57 AM → 11:50 AM
3h 53m • 1 change
9:53 AM → 1:15 PM
3h 22m • 1 change
11:20 AM → 3:05 PM
3h 45m • 1 change
12:32 PM → 4:05 PM
3h 33m • 1 change
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Departing Saturday, October 24, 2026

12:00 AM → 3:10 AM
3h 10m • 1 change
8:00 AM → 11:50 AM
3h 50m • 1 change
9:39 AM → 1:15 PM
3h 36m • 1 change
11:24 AM → 3:05 PM
3h 41m • 1 change
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Departing Sunday, October 25, 2026

12:00 AM → 2:10 AM
3h 10m • 1 change
7:50 AM → 11:50 AM
4h • 1 change
9:28 AM → 1:15 PM
3h 47m • 1 change
11:14 AM → 3:05 PM
3h 51m • 1 change
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Departing Monday, October 26, 2026

7:57 AM → 11:50 AM
3h 53m • 1 change
9:53 AM → 1:15 PM
3h 22m • 1 change
11:20 AM → 3:05 PM
3h 45m • 1 change
12:32 PM → 4:05 PM
3h 33m • 1 change
Show more

Departing Tuesday, October 27, 2026

7:57 AM → 11:50 AM
3h 53m • 1 change
9:53 AM → 1:15 PM
3h 22m • 1 change
11:20 AM → 3:05 PM
3h 45m • 1 change
1:30 PM → 5:10 PM
3h 40m • 1 change
Show more

Frequently asked questions

Want to know about travelling from Avignon Centre to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.