The average bus between Avignon Centre and Lyon takes 3h 37m and the fastest bus takes 2h 56m. The bus service runs several times per day from Avignon Centre to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Avignon Centre and Lyon. The earliest departure is at 12:00 AM at night, and the last departure from Avignon Centre is at 11:42 PM which arrives into Lyon at 12:55 AM. All services require a transfer at Le Lac and take an average of 3h 37m. The schedules shown below are for the next available departures.

3h 50m • 1 change

3h 36m • 1 change

3h 52m • 1 change

3h 41m • 1 change

3h 10m • 1 change

4h • 1 change

3h 47m • 1 change

3h 46m • 1 change

3h 53m • 1 change

3h 22m • 1 change

3h 50m • 1 change

3h 45m • 1 change

3h 53m • 1 change

3h 50m • 1 change

3h 40m • 1 change

3h 54m • 1 change

3h 53m • 1 change

3h 50m • 1 change

3h 54m • 1 change

3h 28m • 1 change

3h 53m • 1 change

3h 50m • 1 change

3h 54m • 1 change

3h 28m • 1 change
Want to know about travelling from Avignon Centre to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Avignon Centre to Lyon. However, there are services departing from Avignon Centre station and arriving at Lyon station via Lyon - Gerland Bus Station station. The journey, including transfers, takes approximately 3h 37m.
Avignon Centre to Lyon bus services, operated by Tecelys, depart from Avignon - Le Pontet - Le Lac Stop station.
Avignon Centre to Lyon bus services, operated by Tecelys, arrive at Lyon - Gerland Bus Station.
The distance between Avignon Centre and Lyon is 200.9 km. The road distance is 239 km.
BlaBlaCar Bus operates a bus from Avignon - Le Pontet - Le Lac Stop to Lyon - Gerland Bus Station every 4 hours. Tickets cost €18–35 and the journey takes 2h 30m. FlixBus also services this route every 4 hours.