Bus Avignon Centre to Lyon from €23 | Tickets & Timetables

Avignon Centre to Lyon buses

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Trip Overview

The average bus between Avignon Centre and Lyon takes 3h 45m and the fastest bus takes 2h 56m. There is a bus service every few hours from Avignon Centre to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 45m
Duration: 241 km
Distance: €23
Average price: Hourly
Frequency

Bus

best

Take the bus from Avignon to Lyonbus FlixBus N1135 / ...

3h 47m

€18–35

Avignon Centre to Lyon bus times

Buses run hourly between Avignon Centre and Lyon. The earliest departure is at 8:01 AM in the morning, and the last departure from Avignon Centre is at 10:34 PM which arrives into Lyon at 12:55 AM. All services require a transfer at Le Lac and take an average of 3h 45m. The schedules shown below are for the next available departures.

Departing Monday, August 10, 2026

1:21 PM → 5:10 PM
3h 49m • 1 change
2:33 PM → 6:35 PM
4h 2m • 1 change
3:09 PM → 6:40 PM
3h 31m • 1 change
3:45 PM → 7:35 PM
3h 50m • 1 change
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Departing Tuesday, August 11, 2026

8:01 AM → 11:50 AM
3h 49m • 1 change
9:46 AM → 1:15 PM
3h 29m • 1 change
10:58 AM → 3:00 PM
4h 2m • 1 change
11:17 AM → 3:05 PM
3h 48m • 1 change
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Departing Wednesday, August 12, 2026

8:01 AM → 11:50 AM
3h 49m • 1 change
9:46 AM → 1:15 PM
3h 29m • 1 change
10:58 AM → 3:00 PM
4h 2m • 1 change
11:17 AM → 3:05 PM
3h 48m • 1 change
Show more

Departing Thursday, August 13, 2026

8:01 AM → 11:50 AM
3h 49m • 1 change
9:46 AM → 1:15 PM
3h 29m • 1 change
10:58 AM → 3:00 PM
4h 2m • 1 change
11:17 AM → 3:05 PM
3h 48m • 1 change
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Departing Friday, August 14, 2026

8:01 AM → 11:50 AM
3h 49m • 1 change
9:46 AM → 1:15 PM
3h 29m • 1 change

Frequently asked questions

Want to know about travelling from Avignon Centre to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.