Avignon Grand Hotel to Lyon Buses

Trip Overview

The average bus between Avignon Grand Hotel and Lyon takes 3h 37m and the fastest bus takes 2h 56m. The bus service runs several times per day from Avignon Grand Hotel to Lyon. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

3h 37m
Duration: 240 km
Distance: €23
Average price: Every 3 hours
Frequency

Bus

best

Take the bus from Avignon to Lyonbus FlixBus N1135 / ...

4h 1m

€16–29

Avignon Grand Hotel to Lyon bus times

Buses run every 3 hours between Avignon Grand Hotel and Lyon. The earliest departure is at 12:00 AM at night, and the last departure from Avignon Grand Hotel is at 11:42 PM which arrives into Lyon at 12:55 AM. All services require a transfer at Gare Centre and take an average of 3h 37m. The schedules shown below are for the next available departures.

Departing Monday, October 19, 2026

9:53 AM → 1:15 PM
3h 22m • 1 change
11:20 AM → 3:05 PM
3h 45m • 1 change
12:32 PM → 4:05 PM
3h 33m • 1 change
1:30 PM → 5:10 PM
3h 40m • 1 change
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Departing Tuesday, October 20, 2026

7:57 AM → 11:50 AM
3h 53m • 1 change
9:53 AM → 1:15 PM
3h 22m • 1 change
11:20 AM → 3:05 PM
3h 45m • 1 change
1:30 PM → 5:10 PM
3h 40m • 1 change
Show more

Departing Wednesday, October 21, 2026

7:57 AM → 11:50 AM
3h 53m • 1 change
9:53 AM → 1:15 PM
3h 22m • 1 change
11:20 AM → 3:05 PM
3h 45m • 1 change
1:30 PM → 5:10 PM
3h 40m • 1 change
Show more

Departing Thursday, October 22, 2026

7:57 AM → 11:50 AM
3h 53m • 1 change
9:53 AM → 1:15 PM
3h 22m • 1 change
11:20 AM → 3:05 PM
3h 45m • 1 change
1:30 PM → 5:10 PM
3h 40m • 1 change
Show more

Departing Friday, October 23, 2026

7:57 AM → 11:50 AM
3h 53m • 1 change
9:53 AM → 1:15 PM
3h 22m • 1 change
11:20 AM → 3:05 PM
3h 45m • 1 change
12:32 PM → 4:05 PM
3h 33m • 1 change
Show more

Departing Saturday, October 24, 2026

12:00 AM → 3:10 AM
3h 10m • 1 change
8:00 AM → 11:50 AM
3h 50m • 1 change
9:39 AM → 1:15 PM
3h 36m • 1 change
11:24 AM → 3:05 PM
3h 41m • 1 change
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Departing Sunday, October 25, 2026

12:00 AM → 2:10 AM
3h 10m • 1 change

Frequently asked questions

Want to know about travelling from Avignon Grand Hotel to Lyon? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Avignon Grand Hotel to Lyon buses

Trip Overview

Bus