The average bus between Barcelona and Mendrisio takes 25h 15m and the fastest bus takes 21h 57m. The bus service runs several times per day from Barcelona to Mendrisio. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Barcelona and Mendrisio. The earliest departure is at 12:50 AM at night, and the last departure from Barcelona is at 7:25 PM which arrives into Mendrisio at 7:22 PM. All services require a transfer at Milan and take an average of 25h 15m. The schedules shown below are for the next available departures.
Arrives next day



30h 44m • 3 changes
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26h 4m • 3 changes
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24h 9m • 3 changes
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30h 32m • 3 changes
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26h 4m • 3 changes
Want to know about travelling from Barcelona to Mendrisio? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Barcelona to Mendrisio. However, there are services departing from Barcelona station and arriving at Mendrisio station via Milan. The journey, including transfers, takes approximately 25h 15m.
Barcelona to Mendrisio bus services, operated by FlixBus, depart from Barcelona station.
Barcelona to Mendrisio bus services, operated by FlixBus, arrive at Como station.
The distance between Barcelona and Mendrisio is 740.9 km. The road distance is 1,069 km.
You can take a bus from Barcelona to Mendrisio, Autosilo via Milan, Como, Como - San Rocchetto, and Chiasso, Stazione in around 17h 4m.