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Big Pine Key to Jacksonville buses

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Trip Overview

The average bus between Big Pine Key and Jacksonville takes 21h 45m and the fastest bus takes 20h 35m. There is at least one bus per day from Big Pine Key to Jacksonville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

21h 45m
Duration
544 mi
Distance
$117
Average price
Once daily
Frequency

Big Pine Key to Jacksonville bus times

Buses run once daily between Big Pine Key and Jacksonville. The service departs Big Pine Key at 5:45 PM in the evening, which arrives into Jacksonville at 14:20:00. All services require a transfer, and take on average 21h 45m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

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    Arrives next day

    Greyhound USAFlixbus USA20h 35m • 1 change

Departing Friday, November 13, 2026

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    Arrives next day

    Greyhound USAGreyhound USA21h • 1 change

Departing Saturday, November 14, 2026

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    Arrives next day

    Greyhound USAFlixbus USA20h 35m • 1 change

Departing Sunday, November 15, 2026

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    Arrives next day

    Greyhound USAFlixbus USA20h 35m • 1 change

Departing Monday, November 16, 2026

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    Arrives next day

    Greyhound USAGreyhound USA21h • 1 change

Departing Tuesday, November 17, 2026

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    Arrives next day

    Greyhound USAGreyhound USA21h • 1 change

Frequently asked questions

Want to know about travelling from Big Pine Key to Jacksonville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Big Pine Key to Jacksonville.ExpandLaunch map view
  • Distance: 543.8 mi
  • Duration: 21h 45m

What companies run services between Big Pine Key, FL, USA and Jacksonville, FL, USA?

You can take a bus from Big Pine Key to Jacksonville via Miami Airport Station in around 13h 40m.

Operators