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Brno Main Train Station to Prague buses

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Trip Overview

The average bus between Brno Main Train Station and Prague takes 2h 39m and the fastest bus takes 2h 20m. There is a bus service every few hours from Brno Main Train Station to Prague. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2h 39m
Duration
207 km
Distance
Kč 650
Average price
Hourly
Frequency

Brno Main Train Station to Prague bus times

Buses run hourly between Brno Main Train Station and Prague. The earliest departure is at 1:30 AM at night, and the last departure from Brno Main Train Station is at 11:30 PM which arrives into Prague at 1:55 AM. All services run direct with no transfers required, and take on average 2h 39m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

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    Arrives next day

    bus bus 2h 25m • Direct

Departing Sunday, November 8, 2026

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    bus bus 2h 25m • Direct
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    bus bus 2h 35m • Direct
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    bus bus 2h 55m • Direct
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    bus bus 2h 55m • Direct
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Departing Monday, November 9, 2026

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    bus bus 2h 25m • Direct
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    bus bus 2h 35m • Direct
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    bus bus 2h 55m • Direct
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    bus bus 2h 55m • Direct
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Departing Tuesday, November 10, 2026

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    bus bus 2h 25m • Direct
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    bus bus 2h 55m • Direct
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    bus bus 2h 55m • Direct
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    bus bus 2h 55m • Direct
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Departing Wednesday, November 11, 2026

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    bus bus 2h 25m • Direct
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    bus bus 2h 55m • Direct
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    bus bus 2h 55m • Direct
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    bus bus 2h 55m • Direct
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Departing Thursday, November 12, 2026

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    bus bus 2h 25m • Direct
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    bus bus 2h 35m • Direct
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    bus bus 2h 55m • Direct
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    bus bus 2h 55m • Direct
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Departing Friday, November 13, 2026

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    bus bus 2h 25m • Direct
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    bus bus 2h 35m • Direct
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    bus bus 2h 55m • Direct
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    bus bus 2h 55m • Direct
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Frequently asked questions

Want to know about travelling from Brno Main Train Station to Prague? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Brno Main Train Station to Prague.ExpandLaunch map view
  • Distance: 207.1 km
  • Duration: 2h 39m

What companies run services between Brno Main Train Station, Czechia and Prague, Czechia?

FlixBus operates a bus from Brno to Prague hourly. Tickets cost Kč 440–700 and the journey takes 2h 35m. Two other operators also service this route.

Operators