The average bus between Brno and Karlovy Vary takes 5h 17m and the fastest bus takes 4h 35m. The bus service runs several times per day from Brno to Karlovy Vary. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Brno and Karlovy Vary. The earliest departure is at 2:55 AM at night, and the last departure from Brno is at 2:40 PM which arrives into Karlovy Vary at 7:55 PM. All services require a transfer, and take on average 5h 17m. The schedules shown below are for the next available departures.

5h 40m • 1 change

5h 40m • 1 change

4h 35m • 1 change

5h 15m • 1 change

6h • 1 change

5h 40m • 1 change

5h 40m • 1 change

4h 35m • 1 change

6h • 1 change

5h 40m • 1 change

5h 40m • 1 change

4h 35m • 1 change

6h • 1 change

5h 40m • 1 change

5h 40m • 1 change

4h 35m • 1 change

6h • 1 change

5h 40m • 1 change

5h 40m • 1 change

4h 35m • 1 change
Want to know about travelling from Brno to Karlovy Vary? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Brno to Karlovy Vary. However, there are services departing from Brno station and arriving at Karlovy Vary station via Praha, ÚAN Florenc. The journey, including transfers, takes approximately 5h 17m.
Brno to Karlovy Vary bus services, operated by FlixBus, depart from Brno station.
Brno to Karlovy Vary bus services, operated by FlixBus, arrive at Karlovy Vary station.
Book your Brno to Karlovy Vary bus tickets online with FlixBus.
The distance between Brno and Karlovy Vary is 292.3 km. The road distance is 346 km.
You can take a bus from Brno to Karlovy Vary via Praha, ÚAN Florenc in around 5h 50m.