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Buffalo to Chicago Union Station buses

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Trip Overview

The average bus between Buffalo and Chicago Union Station takes 12h 32m and the fastest bus takes 11h 55m. The bus service runs several times per day from Buffalo to Chicago Union Station. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

12h 32m
Duration
545 mi
Distance
$118
Average price
Twice daily
Frequency

Buffalo to Chicago Union Station bus times

Buses run twice daily between Buffalo and Chicago Union Station. The earliest departure is at 7:55 AM in the morning, and the last departure from Buffalo is at 11:05 PM which arrives into Chicago Union Station at 10:00 AM. All services require a transfer at Cleveland Bus Station and take an average of 12h 32m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    Greyhound USAGreyhound USA13h 10m • 1 change
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    Arrives next day

    Greyhound USAGreyhound USA11h 55m • 1 change

Departing Friday, November 13, 2026

  •  → 

    Greyhound USAGreyhound USA13h 10m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA11h 55m • 1 change

Departing Saturday, November 14, 2026

  •  → 

    Greyhound USAGreyhound USA13h 10m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA11h 55m • 1 change

Departing Sunday, November 15, 2026

  •  → 

    Greyhound USAGreyhound USA13h 10m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA11h 55m • 1 change

Departing Monday, November 16, 2026

  •  → 

    Greyhound USAGreyhound USA13h 10m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA11h 55m • 1 change

Departing Tuesday, November 17, 2026

  •  → 

    Greyhound USAGreyhound USA13h 10m • 1 change
  •  → 

    Arrives next day

    Greyhound USAGreyhound USA11h 55m • 1 change

Departing Wednesday, November 18, 2026

  •  → 

    Greyhound USAGreyhound USA13h 10m • 1 change

Frequently asked questions

Want to know about travelling from Buffalo to Chicago Union Station? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Buffalo to Chicago Union Station.ExpandLaunch map view
  • Distance: 544.5 mi
  • Duration: 12h 32m

What companies run services between Buffalo, NY, USA and Chicago Union Station, IL, USA?

You can take a bus from Buffalo to Chicago Union Station via Cleveland Bus Station and Chicago Bus Station in around 11h 49m.

Operators