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Buffalo to Lake City buses

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Trip Overview

The average bus between Buffalo and Lake City takes 31h 10m and the fastest bus takes 30h 50m. The bus runs, on average, 3 times per week from Buffalo to Lake City. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

31h 10m
Duration
1,403 mi
Distance
$279
Average price
3 times a week
Frequency

Buffalo to Lake City bus times

Buses run 3 times a week between Buffalo and Lake City. The service departs Buffalo at 10:30 AM in the morning, which arrives into Lake City at 17:20:00. All services require a transfer at Newark Penn Station and take an average of 31h 10m. The schedules shown below are for the next available departures.

Departing Saturday, October 31, 2026

  •  → 

    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA31h 50m • 2 changes

Departing Monday, November 2, 2026

  •  → 

    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA30h 50m • 2 changes

Departing Tuesday, November 3, 2026

  •  → 

    Arrives next day

    Flixbus USAFlixbus USAGreyhound USA30h 50m • 2 changes

Frequently asked questions

Want to know about travelling from Buffalo to Lake City? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Buffalo to Lake City.ExpandLaunch map view
  • Distance: 1,403.1 mi
  • Duration: 31h 10m

What companies run services between Buffalo, NY, USA and Lake City, FL, USA?

You can take a bus from Buffalo to Lake City Bus Station via Newark Penn Station and Jacksonville in around 28h 40m.

Operators