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Buffalo to Mechanicsburg buses

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Trip Overview

The average bus between Buffalo and Mechanicsburg takes 28h 7m and the fastest bus takes 24h 58m. The bus runs, on average, 6 times per week from Buffalo to Mechanicsburg. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

28h 7m
Duration
341 mi
Distance
$110
Average price
6 times a week
Frequency

Buffalo to Mechanicsburg bus times

Buses run 6 times a week between Buffalo and Mechanicsburg. The service departs Buffalo at 2:00 PM in the afternoon, which arrives into Mechanicsburg at 05:58:03. All services require a transfer at DuBois and take an average of 28h 7m. The schedules shown below are for the next available departures.

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Fullington TrailwaysTrailwaysGreyhound USARabbit Transit39h 58m • 3 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives next day

    Fullington TrailwaysTrailwaysGreyhound USARabbit Transit24h 58m • 3 changes

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    Fullington TrailwaysTrailwaysGreyhound USARabbit Transit26h 55m • 3 changes

Departing Tuesday, November 10, 2026

  •  → 

    Arrives next day

    Fullington TrailwaysTrailwaysGreyhound USARabbit Transit26h 55m • 3 changes

Departing Wednesday, November 11, 2026

  •  → 

    Arrives next day

    Fullington TrailwaysTrailwaysGreyhound USARabbit Transit24h 58m • 3 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives next day

    Fullington TrailwaysTrailwaysGreyhound USARabbit Transit24h 58m • 3 changes

Frequently asked questions

Want to know about travelling from Buffalo to Mechanicsburg? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Buffalo to Mechanicsburg.ExpandLaunch map view
  • Distance: 340.9 mi
  • Duration: 28h 7m

What companies run services between Buffalo, NY, USA and Mechanicsburg, Cumberland County, PA, USA?

You can take a bus from Buffalo to E Main St & Arch St WB via DuBois, State College, State College Bus Station, Harrisburg Bus Station, and Market Square Transfer Center in around 10h 44m.

Operators