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Buffalo to Wayne buses

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Trip Overview

The average bus between Buffalo and Wayne takes 15h 26m and the fastest bus takes 11h 53m. The bus service runs several times per day from Buffalo to Wayne. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

15h 26m
Duration
508 mi
Distance
$108
Average price
4 times a day
Frequency

Bus

best
  1. Take the bus from Buffalo to Newark Penn Stationbus bus FlixBus N2686 / ...
  2. Take the bus from Newark Penn Station to Philadelphia Bus Stationbus bus FlixBus 2602 / ...
13h 12m
$81–135

Buffalo to Wayne bus times

Buses run 4 times a day between Buffalo and Wayne. The earliest departure is at 3:30 AM at night, and the last departure from Buffalo is at 11:00 PM which arrives into Wayne at 1:57 PM. All services require a transfer at Newark Penn Station and take an average of 15h 26m. The schedules shown below are for the next available departures.

Departing Monday, October 19, 2026

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    Arrives next day

    Flixbus USAFlixbus USASEPTASEPTA11h 53m • 3 changes

Departing Tuesday, October 20, 2026

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    Flixbus USAGreyhound USASEPTASEPTA13h 23m • 3 changes

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    Flixbus USAGreyhound USASEPTASEPTA13h 26m • 3 changes

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    Arrives next day

    Flixbus USAGreyhound USASEPTASEPTA19h 12m • 3 changes

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    Arrives next day

    Greyhound USAGreyhound USASEPTASEPTA14h 35m • 3 changes
  • Show more

Departing Wednesday, October 21, 2026

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    Flixbus USAGreyhound USASEPTASEPTA13h 23m • 3 changes

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    Arrives next day

    Flixbus USAGreyhound USASEPTASEPTA20h 42m • 3 changes

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    Arrives next day

    Greyhound USAGreyhound USASEPTASEPTA14h 35m • 3 changes

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    Arrives next day

    Flixbus USAFlixbus USASEPTASEPTA14h 57m • 3 changes

Departing Thursday, October 22, 2026

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    Arrives next day

    Flixbus USAGreyhound USASEPTASEPTA19h 12m • 3 changes

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    Arrives next day

    Greyhound USAGreyhound USASEPTASEPTA14h 35m • 3 changes

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    Arrives next day

    Flixbus USAFlixbus USASEPTASEPTA14h 57m • 3 changes

Departing Friday, October 23, 2026

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    Flixbus USAGreyhound USASEPTASEPTA13h 26m • 3 changes

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    Arrives next day

    Flixbus USAGreyhound USASEPTASEPTA20h 10m • 3 changes

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    Arrives next day

    Greyhound USAGreyhound USASEPTASEPTA15h 20m • 3 changes

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    Arrives next day

    Flixbus USAFlixbus USASEPTASEPTA15h 45m • 3 changes

Departing Saturday, October 24, 2026

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    Flixbus USAGreyhound USASEPTASEPTA13h 15m • 3 changes

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    Flixbus USAGreyhound USASEPTASEPTA13h 14m • 3 changes

Departing Sunday, October 25, 2026

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    Arrives next day

    Flixbus USAGreyhound USASEPTASEPTA19h 12m • 3 changes

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    Arrives next day

    Greyhound USAGreyhound USASEPTASEPTA14h 35m • 3 changes

  •  → 

    Arrives next day

    Flixbus USAFlixbus USASEPTASEPTA14h 57m • 3 changes

Departing Monday, October 26, 2026

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    Flixbus USAGreyhound USASEPTASEPTA13h 23m • 3 changes

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    Flixbus USAGreyhound USASEPTASEPTA13h 26m • 3 changes

Frequently asked questions

Want to know about travelling from Buffalo to Wayne? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Buffalo to Wayne.ExpandLaunch map view
  • Distance: 507.9 mi
  • Duration: 15h 26m

What companies run services between Buffalo, NY, USA and Wayne, PA, USA?

You can take a bus from Buffalo to Lancaster Av & Wayne Av via Newark Penn Station, Philadelphia Bus Station, Market St & 10th St - MBFS, Coulter Av & Glenn Rd, and Lancaster Av & Station Av - FS in around 13h 12m.

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