The average bus between Cancún and Guanajuato takes 34h 35m and the fastest bus takes 33h 50m. The bus service runs several times per day from Cancún to Guanajuato. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Cancún and Guanajuato. The earliest departure is at 10:30 AM in the morning, and the last departure from Cancún is at 6:30 PM which arrives into Guanajuato at 4:50 AM. All services require a transfer, and take on average 34h 35m. The schedules shown below are for the next available departures.
Arrives next day

32h 50m • 1 change
Arrives +2 days

34h 20m • 1 change
Arrives next day

32h 50m • 1 change
Arrives +2 days

34h 20m • 1 change
Arrives next day

32h 50m • 1 change
Arrives +2 days

34h 20m • 1 change
Arrives next day

32h 50m • 1 change
Arrives +2 days

34h 20m • 1 change
Want to know about travelling from Cancún to Guanajuato? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Cancún to Guanajuato. However, there are services departing from Cancún station and arriving at Guanajuato station via Terminal Central de Autobuses del Norte. The journey, including transfers, takes approximately 34h 35m.
Cancún to Guanajuato bus services, operated by ADO, depart from Terminal de Autobuses ADO Cancún station.
Cancún to Guanajuato bus services, operated by ADO, arrive at Guanajuato station.
Book your Cancún to Guanajuato bus tickets online with ADO, Primera Plus and ETN Turistar.
The distance between Cancún and Guanajuato is 1,494.8 km. The road distance is 2,002 km.
You can take a bus from Terminal de Autobuses ADO Cancún to Guanajuato via Terminal Central de Autobuses del Norte in around 33h 5m.