The average bus between Cancún and Tlaxcala takes 28h 48m and the fastest bus takes 27h 40m. The bus service runs several times per day from Cancún to Tlaxcala. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Cancún and Tlaxcala. The earliest departure is at 9:45 AM in the morning, and the last departure from Cancún is at 5:00 PM which arrives into Tlaxcala at 10:10 PM. All services require a transfer at Puebla Capu and take an average of 28h 48m. The schedules shown below are for the next available departures.
Arrives next day

27h 55m • 1 change
Arrives next day

27h 30m • 1 change
Arrives next day

26h 40m • 1 change
Arrives next day

29h 10m • 1 change
Arrives next day

27h 55m • 1 change
Arrives next day

27h 30m • 1 change
Arrives next day

26h 40m • 1 change
Arrives next day

29h 10m • 1 change
Arrives next day

27h 55m • 1 change
Arrives next day

27h 30m • 1 change
Arrives next day

26h 40m • 1 change
Arrives next day

29h 10m • 1 change
Want to know about travelling from Cancún to Tlaxcala? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Cancún to Tlaxcala. However, there are services departing from Cancún station and arriving at Tlaxcala station via Puebla Capu. The journey, including transfers, takes approximately 28h 48m.
Cancún to Tlaxcala bus services, operated by ADO, depart from Terminal de Autobuses ADO Cancún station.
Cancún to Tlaxcala bus services, operated by ADO, arrive at Puebla Capu station.
The distance between Cancún and Tlaxcala is 1,202 km. The road distance is 1,575 km.
ADO operates a bus from Terminal de Autobuses ADO Cancún to Puebla Capu every 4 hours. Tickets cost $2,100–4,300 and the journey takes 25h 45m.