Cardinal Hotel St. Peter, Rome to Florence Buses

Cardinal Hotel St. Peter, Rome to Florence buses

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Trip Overview

The average bus between Cardinal Hotel St. Peter, Rome and Florence takes 4h 36m and the fastest bus takes 4h 6m. There is a bus service every few hours from Cardinal Hotel St. Peter, Rome to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

4h 36m
Duration: 290 km
Distance: €42
Average price: Hourly
Frequency

Line 490 bus, bus

best

Take the bus from Emo/Di Bartolo to Roma, Autostazione Tiburtinabus 490 / ...
Take the bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Stationbus 510 / ...

4h 48m

€16–58

Cardinal Hotel St. Peter, Rome to Florence bus times

Buses run hourly between Cardinal Hotel St. Peter, Rome and Florence. The earliest departure is at 5:17 AM in the morning, and the last departure from Cardinal Hotel St. Peter, Rome is at 10:02 PM which arrives into Florence at 2:10 AM. All services require a transfer at Leone Xiii/Pio Xi and take an average of 4h 36m. The schedules shown below are for the next available departures.

Departing Tuesday, November 3, 2026

8:47 PM → 1:00 AM
Arrives next day
4h 12m • 2 changes

Departing Wednesday, November 4, 2026

6:50 AM → 11:10 AM
4h 19m • 2 changes
7:03 AM → 11:45 AM
4h 41m • 2 changes
7:29 AM → 12:30 PM
5h • 2 changes
8:54 AM → 1:25 PM
4h 30m • 2 changes
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Departing Thursday, November 5, 2026

5:25 AM → 10:15 AM
4h 49m • 2 changes
6:50 AM → 11:10 AM
4h 19m • 2 changes
7:03 AM → 11:45 AM
4h 41m • 2 changes
7:29 AM → 12:30 PM
5h • 2 changes
Show more

Departing Friday, November 6, 2026

5:25 AM → 10:15 AM
4h 49m • 2 changes
6:50 AM → 11:10 AM
4h 19m • 2 changes
7:03 AM → 11:45 AM
4h 41m • 2 changes
7:29 AM → 12:30 PM
5h • 2 changes
Show more

Departing Saturday, November 7, 2026

5:34 AM → 10:15 AM
4h 40m • 2 changes
6:45 AM → 11:10 AM
4h 24m • 2 changes
7:29 AM → 11:45 AM
4h 15m • 2 changes
7:38 AM → 12:30 PM
4h 51m • 2 changes
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Departing Sunday, November 8, 2026

5:17 AM → 10:15 AM
4h 57m • 2 changes
6:33 AM → 11:10 AM
4h 36m • 2 changes
7:04 AM → 11:45 AM
4h 40m • 2 changes
7:43 AM → 12:30 PM
4h 46m • 2 changes
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Departing Monday, November 9, 2026

5:25 AM → 10:15 AM
4h 49m • 2 changes
6:50 AM → 11:10 AM
4h 19m • 2 changes
7:03 AM → 11:45 AM
4h 41m • 2 changes
7:29 AM → 12:30 PM
5h • 2 changes
Show more

Departing Tuesday, November 10, 2026

5:25 AM → 10:15 AM
4h 49m • 2 changes
6:50 AM → 11:10 AM
4h 19m • 2 changes
7:03 AM → 11:45 AM
4h 41m • 2 changes
7:29 AM → 12:30 PM
5h • 2 changes
Show more

Frequently asked questions

Want to know about travelling from Cardinal Hotel St. Peter, Rome to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.