The average bus between Carlisle and Chicago takes 21h 35m and the fastest bus takes 17h 34m. There is at least one bus per day from Carlisle to Chicago. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Carlisle and Chicago. The earliest departure is at 1:36 PM in the afternoon, and the last departure from Carlisle is at 7:06 PM which arrives into Chicago at 6:55 PM. All services require a transfer at Market Square Transfer Center and take an average of 21h 35m. The schedules shown below are for the next available departures.
Arrives next day

16h 34m • 1 change
Arrives next day

23h 49m • 1 change
Arrives next day

16h 34m • 1 change
Arrives next day

23h 49m • 1 change
Want to know about travelling from Carlisle to Chicago? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Carlisle to Chicago. However, there are services departing from Carlisle station and arriving at Chicago station via Chicago Bus Station station. The journey, including transfers, takes approximately 21h 35m.
Carlisle to Chicago bus services, operated by Rabbit Transit, depart from Harrisburg Bus Station.
Carlisle to Chicago bus services, operated by Rabbit Transit, arrive at Chicago Bus Station.
The distance between Carlisle and Chicago is 894.5 km. The road distance is 1,284 km.
Flixbus USA operates a bus from Harrisburg Bus Station to Chicago Bus Station once daily. Tickets cost $120–220 and the journey takes 16h 30m.