The average bus between Carlisle and Indianapolis takes 17h 9m and the fastest bus takes 13h 24m. There is at least one bus per day from Carlisle to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run once daily between Carlisle and Indianapolis. The earliest departure is at 1:36 PM in the afternoon, and the last departure from Carlisle is at 7:06 PM which arrives into Indianapolis at 4:00 PM. All services require a transfer at Market Square Transfer Center and take an average of 17h 9m. The schedules shown below are for the next available departures.
Arrives next day

13h 24m • 1 change
Arrives next day

20h 54m • 1 change
Arrives next day

13h 24m • 1 change
Arrives next day

20h 54m • 1 change
Want to know about travelling from Carlisle to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Carlisle to Indianapolis. However, there are services departing from Carlisle station and arriving at Indianapolis station via Indianapolis. The journey, including transfers, takes approximately 17h 9m.
Carlisle to Indianapolis bus services, operated by Rabbit Transit, depart from Harrisburg Bus Station.
Carlisle to Indianapolis bus services, operated by Rabbit Transit, arrive at Indianapolis station.
The distance between Carlisle and Indianapolis is 765.4 km. The road distance is 980 km.
Flixbus USA operates a bus from Harrisburg Bus Station to Indianapolis once daily. Tickets cost $95–160 and the journey takes 12h 20m.