The average bus between Carlisle and Manhattan takes 8h 26m and the fastest bus takes 5h 49m. The bus service runs several times per day from Carlisle to Manhattan. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Carlisle and Manhattan. The earliest departure is at 10:36 AM in the morning, and the last departure from Carlisle is at 7:06 PM which arrives into Manhattan at 6:40 AM. All services require a transfer at Market Square Transfer Center and take an average of 8h 26m. The schedules shown below are for the next available departures.

5h 49m • 1 change

7h 24m • 1 change
Arrives next day

11h 34m • 1 change

5h 49m • 1 change

7h 24m • 1 change
Arrives next day

11h 34m • 1 change
Want to know about travelling from Carlisle to Manhattan? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Carlisle to Manhattan. However, there are services departing from Carlisle station and arriving at Manhattan station via New York Midtown. The journey, including transfers, takes approximately 8h 26m.
Carlisle to Manhattan bus services, operated by Rabbit Transit, depart from Harrisburg Bus Station.
Carlisle to Manhattan bus services, operated by Rabbit Transit, arrive at New York Midtown station.
The distance between Carlisle and Manhattan is 280.1 km. The road distance is 384 km.
Flixbus USA operates a bus from Harrisburg Bus Station to New York Midtown twice daily. Tickets cost $35–60 and the journey takes 4h 10m.