The average bus between Cartagena and Santander takes 14h 20m and the fastest bus takes 11h 15m. The bus service runs several times per day from Cartagena to Santander. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 4 times a day between Cartagena and Santander. The earliest departure is at 7:15 AM in the morning, and the last departure from Cartagena is at 11:15 PM which arrives into Santander at 4:15 PM. All services require a transfer, and take on average 14h 20m. The schedules shown below are for the next available departures.

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Want to know about travelling from Cartagena to Santander? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Cartagena to Santander. However, there are services departing from Cartagena station and arriving at Santander station via Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid). The journey, including transfers, takes approximately 14h 20m.
Cartagena to Santander bus services, operated by ALSA, depart from Cartagena station.
Cartagena to Santander bus services, operated by ALSA, arrive at Estación de autobuses de Santander station.
Book your Cartagena to Santander bus tickets online with ALSA.
The distance between Cartagena and Santander is 693.6 km. The road distance is 860 km.
You can take a bus from Cartagena to Estación de autobuses de Santander via Madrid, Terminal de autobuses T4 (Aeropuerto de Madrid) in around 11h 55m.