The average bus between Cassino and Brindisi takes 8h 32m and the fastest bus takes 7h 45m. The bus service runs several times per day from Cassino to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Cassino and Brindisi. The earliest departure is at 9:45 AM in the morning, and the last departure from Cassino is at 8:30 PM which arrives into Brindisi at 6:10 AM. All services require a transfer, and take on average 8h 32m. The schedules shown below are for the next available departures.

7h 45m • 1 change

8h • 1 change
Arrives next day

10h 20m • 1 change

7h 45m • 1 change

8h • 1 change
Arrives next day

9h 40m • 1 change

7h 45m • 1 change

8h • 1 change
Arrives next day

9h 40m • 1 change

7h 45m • 1 change

8h • 1 change
Arrives next day

9h 40m • 1 change

7h 45m • 1 change

8h • 1 change
Arrives next day

9h 40m • 1 change
Want to know about travelling from Cassino to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Cassino to Brindisi. However, there are services departing from Cassino station and arriving at Brindisi station via Napoli P.zza Garibaldi. The journey, including transfers, takes approximately 8h 32m.
Cassino to Brindisi bus services, operated by FlixBus, depart from Cassino station.
Cassino to Brindisi bus services, operated by FlixBus, arrive at Brindisi station.
Book your Cassino to Brindisi bus tickets online with FlixBus.
The distance between Cassino and Brindisi is 357.2 km. The road distance is 468 km.
You can take a bus from Cassino to Brindisi via Napoli P.zza Garibaldi in around 7h 10m.