The average bus between Cassino and Brindisi takes 8h 34m and the fastest bus takes 7h 49m. The bus service runs several times per day from Cassino to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Cassino and Brindisi. The earliest departure is at 9:45 AM in the morning, and the last departure from Cassino is at 8:30 PM which arrives into Brindisi at 6:10 AM. All services require a transfer, and take on average 8h 34m. The schedules shown below are for the next available departures.

7h 49m • 1 change
8h • 1 changeArrives next day

10h 30m • 1 change
7h 49m • 1 change
8h • 1 changeArrives next day

10h 30m • 1 change
7h 49m • 1 change
8h • 1 changeArrives next day

9h 40m • 1 change
7h 49m • 1 change
8h • 1 changeArrives next day

9h 40m • 1 changeWant to know about travelling from Cassino to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Cassino to Brindisi. However, there are services departing from Cassino station and arriving at Brindisi station via Napoli P.zza Garibaldi. The journey, including transfers, takes approximately 8h 34m.
Cassino to Brindisi bus services, operated by FlixBus, depart from Cassino station.
Cassino to Brindisi bus services, operated by FlixBus, arrive at Brindisi station.
Book your Cassino to Brindisi bus tickets online with FlixBus.
The distance between Cassino and Brindisi is 357.2 km. The road distance is 472 km.
You can take a bus from Cassino to Brindisi via Napoli P.zza Garibaldi in around 7h 20m.