The average bus between Castel Sant'Angelo and Florence takes 4h 12m and the fastest bus takes 3h 47m. The bus service runs several times per day from Castel Sant'Angelo to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 3 hours between Castel Sant'Angelo and Florence. The earliest departure is at 6:20 AM in the morning, and the last departure from Castel Sant'Angelo is at 10:22 PM which arrives into Florence at 2:10 AM. All services require a transfer at Cicerone/Cavour and take an average of 4h 12m. The schedules shown below are for the next available departures.

3h 54m • 1 change

3h 50m • 1 change

3h 52m • 1 change

4h 16m • 1 change

3h 54m • 1 change

3h 50m • 1 change

3h 52m • 1 change

4h 16m • 1 change

3h 50m • 1 change

3h 47m • 1 change

4h 5m • 1 change

3h 58m • 1 change
Want to know about travelling from Castel Sant'Angelo to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Castel Sant'Angelo to Florence. However, there are services departing from Castel Sant'Angelo station and arriving at Florence station via Florence Villa Constanza Bus Station station. The journey, including transfers, takes approximately 4h 12m.
Castel Sant'Angelo to Florence bus services, operated by ATAC S.p.A. Azienda per la mobilità, depart from Roma, Autostazione Tiburtina station.
Castel Sant'Angelo to Florence bus services, operated by ATAC S.p.A. Azienda per la mobilità, arrive at Florence Villa Constanza Bus Station.
The distance between Castel Sant'Angelo and Florence is 231.1 km. The road distance is 286 km.
FlixBus operates a bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Station hourly. Tickets cost €23–40 and the journey takes 3h 15m. Three other operators also service this route.