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Champaign to Mayo Clinic buses

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Trip Overview

The average bus between Champaign and Mayo Clinic takes 19h 50m and the fastest bus takes 19h 35m. The bus runs, on average, 4 times per week from Champaign to Mayo Clinic. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

19h 50m
Duration
503 mi
Distance
$164
Average price
4 times a week
Frequency

Champaign to Mayo Clinic bus times

Buses run 4 times a week between Champaign and Mayo Clinic. The service departs Champaign at 6:05 PM in the evening, which arrives into Mayo Clinic at 14:40:00. All services require a transfer at Chicago Bus Station and take an average of 19h 50m. The schedules shown below are for the next available departures.

Departing Monday, October 26, 2026

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    Arrives next day

    Flixbus USAGreyhound USAJefferson Lines19h 35m • 2 changes

Departing Tuesday, October 27, 2026

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    Arrives next day

    Flixbus USAGreyhound USAJefferson Lines19h 35m • 2 changes

Departing Friday, October 30, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USAJefferson Lines19h 35m • 2 changes

Departing Saturday, October 31, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USAJefferson Lines20h 35m • 2 changes

Frequently asked questions

Want to know about travelling from Champaign to Mayo Clinic? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Champaign to Mayo Clinic.ExpandLaunch map view
  • Distance: 502.7 mi
  • Duration: 19h 50m

What companies run services between Champaign, IL, USA and Mayo Clinic, MN, USA?

You can take a bus from Champaign Intermodal Trans Ctr to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 11h 53m.

Operators