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Champaign to Mayo Clinic buses

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Trip Overview

The average bus between Champaign and Mayo Clinic takes 20h 55m and the fastest bus takes 19h 35m. The bus runs, on average, 6 times per week from Champaign to Mayo Clinic. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

20h 55m
Duration
503 mi
Distance
$165
Average price
6 times a week
Frequency

Champaign to Mayo Clinic bus times

Buses run 6 times a week between Champaign and Mayo Clinic. The earliest departure is at 10:00 AM in the morning, and the last departure from Champaign is at 6:05 PM which arrives into Mayo Clinic at 2:40 PM. All services require a transfer at Chicago Bus Station and take an average of 20h 55m. The schedules shown below are for the next available departures.

Departing Thursday, November 5, 2026

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    Arrives next day

    Peoria Charter Coach CompanyGreyhound USAJefferson Lines27h 40m • 2 changes

Departing Friday, November 6, 2026

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    Arrives next day

    Flixbus USAGreyhound USAJefferson Lines19h 35m • 2 changes

Departing Saturday, November 7, 2026

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    Arrives next day

    Flixbus USAGreyhound USAJefferson Lines19h 35m • 2 changes

Departing Sunday, November 8, 2026

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    Arrives next day

    Flixbus USAGreyhound USAJefferson Lines19h 35m • 2 changes

Departing Monday, November 9, 2026

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    Arrives next day

    Flixbus USAGreyhound USAJefferson Lines19h 35m • 2 changes

Departing Tuesday, November 10, 2026

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    Arrives next day

    Flixbus USAGreyhound USAJefferson Lines19h 35m • 2 changes

Frequently asked questions

Want to know about travelling from Champaign to Mayo Clinic? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Champaign to Mayo Clinic.ExpandLaunch map view
  • Distance: 502.7 mi
  • Duration: 20h 55m

What companies run services between Champaign, IL, USA and Mayo Clinic, MN, USA?

You can take a bus from Champaign Intermodal Trans Ctr to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 11h 46m.

Operators