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Charleston to Indianapolis buses

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Trip Overview

The average bus between Charleston and Indianapolis takes 39h 39m and the fastest bus takes 36h 55m. The bus runs, on average, 5 times per week from Charleston to Indianapolis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

39h 39m
Duration
1,044 mi
Distance
$214
Average price
5 times a week
Frequency

Charleston to Indianapolis bus times

Buses run 5 times a week between Charleston and Indianapolis. The earliest departure is at 8:34 AM in the morning, and the last departure from Charleston is at 7:14 PM which arrives into Indianapolis at 9:40 PM. All services require a transfer at N. Charleston SuperStop and take an average of 39h 39m. The schedules shown below are for the next available departures.

Departing Friday, November 6, 2026

  •  → 

    Arrives next day

    CARTACARTAGreyhound USAFlixbus USA36h 55m • 3 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives next day

    CARTACARTAGreyhound USAFlixbus USA37h 6m • 3 changes
  •  → 

    Arrives +2 days

    CARTACARTAGreyhound USAFlixbus USA2d 2h • 3 changes

Departing Monday, November 9, 2026

  •  → 

    Arrives next day

    CARTACARTAGreyhound USAFlixbus USA36h 55m • 3 changes

Frequently asked questions

Want to know about travelling from Charleston to Indianapolis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Charleston to Indianapolis.ExpandLaunch map view
  • Distance: 1,044.2 mi
  • Duration: 39h 39m

What companies run services between Charleston, SC, USA and Indianapolis, IN, USA?

You can take a bus from Mary St / Meeting St to Indianapolis via N. Charleston SuperStop, North Charleston Transit Center, Charleston Bus Station, and Atlanta Bus Station in around 26h 43m.

Operators