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Charleston to Key West buses

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Trip Overview

The bus between Charleston and Key West takes 37h 27m. The bus runs, on average, 5 times per week from Charleston to Key West. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

37h 27m
Duration
1,187 mi
Distance
$230
Average price
5 times a week
Frequency

Charleston to Key West bus times

Buses run 5 times a week between Charleston and Key West. The service departs Charleston at 11:35 PM at night, which arrives into Key West at 13:02:00. All services require a transfer at Charlotte Bus Station and take an average of 37h 27m. The schedules shown below are for the next available departures.

Departing Wednesday, November 4, 2026

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    Arrives +2 days

    Barons BusFlixbus USAFlixbus USAGreyhound USAKey West Transit37h 27m • 4 changes

Departing Thursday, November 5, 2026

  •  → 

    Arrives +2 days

    Barons BusFlixbus USAFlixbus USAGreyhound USAKey West Transit37h 27m • 4 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives +2 days

    Barons BusFlixbus USAFlixbus USAGreyhound USAKey West Transit37h 27m • 4 changes

Departing Saturday, November 7, 2026

  •  → 

    Arrives +2 days

    Barons BusFlixbus USAFlixbus USAGreyhound USAKey West Transit37h 27m • 4 changes

Departing Sunday, November 8, 2026

  •  → 

    Arrives +2 days

    Barons BusFlixbus USAFlixbus USAGreyhound USAKey West Transit37h 27m • 4 changes

Frequently asked questions

Want to know about travelling from Charleston to Key West? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Charleston to Key West.ExpandLaunch map view
  • Distance: 1,187.1 mi
  • Duration: 37h 27m

What companies run services between Charleston, WV, USA and Key West, FL, USA?

You can take a bus from Charleston to N Roosevelt & 3rd Street via Charlotte Bus Station, Orlando Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 28h 25m.

Operators