Rome2Rio

Charlotte to Key West (Island) buses

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Trip Overview

The bus between Charlotte and Key West (Island) takes 22h 30m. The bus runs, on average, 6 times per week from Charlotte to Key West (Island). The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

22h 30m
Duration
914 mi
Distance
$185
Average price
6 times a week
Frequency

Charlotte to Key West (Island) bus times

Buses run 6 times a week between Charlotte and Key West (Island). The service departs Charlotte at 11:00 AM in the morning, which arrives into Key West (Island) at 09:30:00. All services require a transfer at Orlando Bus Station and take an average of 22h 30m. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA22h 30m • 2 changes

Departing Thursday, November 12, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA22h 30m • 2 changes

Departing Friday, November 13, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA22h 30m • 2 changes

Departing Saturday, November 14, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA22h 30m • 2 changes

Departing Sunday, November 15, 2026

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    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA22h 30m • 2 changes

Departing Monday, November 16, 2026

  •  → 

    Arrives next day

    Flixbus USAGreyhound USAGreyhound USA22h 30m • 2 changes

Frequently asked questions

Want to know about travelling from Charlotte to Key West (Island)? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Charlotte to Key West (Island).ExpandLaunch map view
  • Distance: 914.3 mi
  • Duration: 22h 30m

What companies run services between Charlotte, NC, USA and Key West (Island), FL, USA?

You can take a bus from Charlotte Bus Station to Key West Airport via Orlando Bus Station and Miami Airport Station in around 21h 23m.

Operators