The average bus between Cheltenham and Southampton takes 5h 9m and the fastest bus takes 4h 5m. The bus service runs several times per day from Cheltenham to Southampton. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 4 hours between Cheltenham and Southampton. The earliest departure is at 3:00 AM at night, and the last departure from Cheltenham is at 4:30 PM which arrives into Southampton at 9:00 PM. All services require a transfer, and take on average 5h 9m. The schedules shown below are for the next available departures.

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4h 55m • 1 change
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4h 15m • 1 change
6h 10m • 1 change
5h 35m • 1 change
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5h 45m • 1 changeWant to know about travelling from Cheltenham to Southampton? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Cheltenham to Southampton. However, there are services departing from Cheltenham station and arriving at Southampton station via Heathrow Central Bus Station station. The journey, including transfers, takes approximately 5h 9m.
Cheltenham to Southampton bus services, operated by National Express, depart from Royal Well Bus Station.
Cheltenham to Southampton bus services, operated by National Express, arrive at Coach Station.
Book your Cheltenham to Southampton bus tickets online with National Express.
The distance between Cheltenham and Southampton is 120.3 km. The road distance is 261 km.
You can take a bus from Royal Well Bus Station to Coach Station via Heathrow Central Bus Station in around 4h 33m.