Rome2Rio

Chicago Union Station to Des Moines buses

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Trip Overview

The average bus between Chicago Union Station and Des Moines takes 9h 2m and the fastest bus takes 8h 25m. The bus service runs several times per day from Chicago Union Station to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

9h 2m
Duration
340 mi
Distance
$70
Average price
Twice daily
Frequency

Chicago Union Station to Des Moines bus times

Buses run twice daily between Chicago Union Station and Des Moines. The earliest departure is at 6:10 AM in the morning, and the last departure from Chicago Union Station is at 8:50 AM which arrives into Des Moines at 6:45 PM. All services run direct with no transfers required, and take on average 9h 2m. The schedules shown below are for the next available departures.

Departing Thursday, November 12, 2026

  •  → 

    bus bus 9h 55m • Direct

Departing Friday, November 13, 2026

  •  → 

    bus bus 8h 25m • Direct
  •  → 

    bus bus 9h 55m • Direct

Departing Saturday, November 14, 2026

  •  → 

    bus bus 8h 25m • Direct
  •  → 

    bus bus 9h 55m • Direct

Departing Sunday, November 15, 2026

  •  → 

    bus bus 8h 25m • Direct
  •  → 

    bus bus 9h 55m • Direct

Departing Monday, November 16, 2026

  •  → 

    bus bus 8h 25m • Direct

Departing Tuesday, November 17, 2026

  •  → 

    bus bus 8h 25m • Direct

Departing Wednesday, November 18, 2026

  •  → 

    bus bus 8h 25m • Direct
  •  → 

    bus bus 9h 55m • Direct

Frequently asked questions

Want to know about travelling from Chicago Union Station to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Chicago Union Station to Des Moines.ExpandLaunch map view
  • Distance: 340.5 mi
  • Duration: 9h 2m

What companies run services between Chicago Union Station, IL, USA and Des Moines, IA, USA?

Greyhound USA operates a bus from Chicago Bus Station to Des Moines 3 times a day. Tickets cost $60–90 and the journey takes 6h 30m.

Operators