The average bus between Chicago Union Station and Saint Charles takes 10h 22m and the fastest bus takes 7h 24m. The bus service runs several times per day from Chicago Union Station to Saint Charles. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Chicago Union Station and Saint Charles. The earliest departure is at 12:15 AM at night, and the last departure from Chicago Union Station is at 5:05 PM which arrives into Saint Charles at 5:49 AM. All services require a transfer at Chicago Bus Station and take an average of 10h 22m. The schedules shown below are for the next available departures.


8h 54m • 2 changes


8h 24m • 2 changes
Arrives next day


12h 44m • 2 changes


7h 54m • 2 changes


7h 24m • 2 changes
Arrives next day


12h 44m • 2 changes


7h 54m • 2 changes


7h 24m • 2 changes
Arrives next day


12h 44m • 2 changes


7h 54m • 2 changes


7h 24m • 2 changes
Arrives next day


12h 44m • 2 changes
Want to know about travelling from Chicago Union Station to Saint Charles? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Chicago Union Station to Saint Charles. However, there are services departing from Chicago Union Station station and arriving at Saint Charles station via St Louis Bus Station station. The journey, including transfers, takes approximately 10h 22m.
Chicago Union Station to Saint Charles bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago Union Station to Saint Charles bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
The distance between Chicago Union Station and Saint Charles is 420 km. The road distance is 547 km.
FlixBus-us operates a bus from Chicago Bus Station to St Louis Bus Station 3 times a day, and the journey takes 5h 55m. Flixbus USA also services this route twice daily.