Rome2Rio

Chicago to Florence buses

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Trip Overview

The average bus between Chicago and Florence takes 8h and the fastest bus takes 7h 52m. The bus runs, on average, 5 times per week from Chicago to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

8h
Duration
316 mi
Distance
$60
Average price
5 times a week
Frequency

Chicago to Florence bus times

Buses run 5 times a week between Chicago and Florence. The earliest departure is at 7:00 AM in the morning, and the last departure from Chicago is at 10:30 AM which arrives into Florence at 7:22 PM. All services require a transfer at Cincinnati and take an average of 8h. The schedules shown below are for the next available departures.

Departing Tuesday, November 3, 2026

  •  → 

    Flixbus USAGo MetroTANK8h 11m • 2 changes
  •  → 

    Flixbus USAGo MetroTANK7h 52m • 2 changes

Departing Thursday, November 5, 2026

  •  → 

    Flixbus USAGo MetroTANK7h 52m • 2 changes

Departing Friday, November 6, 2026

  •  → 

    Flixbus USAGo MetroTANK8h 11m • 2 changes
  •  → 

    Flixbus USAGo MetroTANK7h 52m • 2 changes

Frequently asked questions

Want to know about travelling from Chicago to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Chicago to Florence.ExpandLaunch map view
  • Distance: 316.4 mi
  • Duration: 8h

What companies run services between Chicago, IL, USA and Florence, KY, USA?

Flixbus USA operates a bus from Chicago Bus Station to Cincinnati twice daily. Tickets cost $45–70 and the journey takes 5h 45m.

Operators