Rome2Rio

Chicago to Florence buses

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Trip Overview

The bus between Chicago and Florence takes 2d 6h. The bus runs, on average, 5 times per week from Chicago to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 6h
Duration
926 mi
Distance
$170
Average price
5 times a week
Frequency

Chicago to Florence bus times

Buses run 5 times a week between Chicago and Florence. The service departs Chicago at 6:50 AM in the morning, which arrives into Florence at 13:30:00. All services require a transfer at Columbus and take an average of 2d 6h. The schedules shown below are for the next available departures.

Departing Wednesday, November 11, 2026

  •  → 

    Arrives +2 days

    Barons BusBarons BusGreyhound USAGreyhound USA2d 6h • 3 changes

Departing Thursday, November 12, 2026

  •  → 

    Arrives +2 days

    Barons BusBarons BusGreyhound USAGreyhound USA2d 6h • 3 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Barons BusBarons BusGreyhound USAGreyhound USA2d 6h • 3 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Barons BusBarons BusGreyhound USAGreyhound USA2d 6h • 3 changes

Frequently asked questions

Want to know about travelling from Chicago to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Chicago to Florence.ExpandLaunch map view
  • Distance: 926.5 mi
  • Duration: 2d 6h

What companies run services between Chicago, IL, USA and Florence, SC, USA?

You can take a bus from Chicago to Florence Bus Station via Columbus, Charlotte Bus Station, and Camden in around 23h 25m.

Operators