Rome2Rio

Chicago to Louisville, KY buses

Find Transport to Louisville, KY

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Trip Overview

The average bus between Chicago and Louisville, KY takes 6h 43m and the fastest bus takes 6h 5m. The bus service runs several times per day from Chicago to Louisville, KY. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

6h 43m
Duration
298 mi
Distance
$55
Average price
Every 4 hours
Frequency

Chicago to Louisville, KY bus times

Buses run every 4 hours between Chicago and Louisville, KY. The earliest departure is at 6:10 AM in the morning, and the last departure from Chicago is at 11:10 PM which arrives into Louisville, KY at 6:55 AM. All services run direct with no transfers required, and take on average 6h 43m. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives next day

    bus bus 6h 55m • Direct
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    Arrives next day

    bus bus 6h 45m • Direct

Departing Wednesday, November 11, 2026

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    bus bus 6h 5m • Direct
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    bus bus 6h 45m • Direct
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    bus bus 8h 5m • Direct
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    bus bus 6h 15m • Direct
  • Show more

Departing Thursday, November 12, 2026

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    bus bus 6h 5m • Direct
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    bus bus 6h 45m • Direct
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    bus bus 8h 5m • Direct
  •  → 

    bus bus 6h 15m • Direct
  • Show more

Departing Friday, November 13, 2026

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    bus bus 6h 5m • Direct
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    bus bus 6h 45m • Direct
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    bus bus 8h 5m • Direct
  •  → 

    bus bus 6h 15m • Direct
  • Show more

Departing Saturday, November 14, 2026

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    bus bus 6h 5m • Direct
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    bus bus 6h 45m • Direct
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    bus bus 8h 5m • Direct
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    bus bus 6h 15m • Direct
  • Show more

Departing Sunday, November 15, 2026

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    bus bus 6h 5m • Direct
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    bus bus 6h 45m • Direct
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    bus bus 8h 5m • Direct
  •  → 

    bus bus 6h 15m • Direct
  • Show more

Departing Monday, November 16, 2026

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    bus bus 6h 5m • Direct
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    bus bus 6h 45m • Direct
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    bus bus 8h 5m • Direct
  •  → 

    bus bus 6h 15m • Direct
  • Show more

Frequently asked questions

Want to know about travelling from Chicago to Louisville, KY? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Chicago to Louisville, KY.ExpandLaunch map view
  • Distance: 298.2 mi
  • Duration: 6h 43m

What companies run services between Chicago, IL, USA and Louisville, KY, USA?

Greyhound USA operates a bus from Chicago Bus Station to Louisville Bus Station 4 times a day. Tickets cost $50–80 and the journey takes 6h 55m. Two other operators also service this route.

Operators