The average bus between Chicago and Missouri Botanical Garden takes 9h 39m and the fastest bus takes 7h 3m. The bus service runs several times per day from Chicago to Missouri Botanical Garden. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Chicago and Missouri Botanical Garden. The earliest departure is at 12:15 AM at night, and the last departure from Chicago is at 5:05 PM which arrives into Missouri Botanical Garden at 4:45 AM. All services require a transfer at St Louis Bus Station and take an average of 9h 39m. The schedules shown below are for the next available departures.

7h 33m • 1 change

7h 5m • 1 change
Arrives next day

11h 40m • 1 change

7h 33m • 1 change

7h 5m • 1 change
Arrives next day

12h 40m • 1 change

7h 32m • 1 change

7h 3m • 1 change
Arrives next day

12h 40m • 1 change

7h 32m • 1 change

7h 3m • 1 change
Arrives next day

11h 40m • 1 change

7h 33m • 1 change

7h 5m • 1 change
Arrives next day

11h 40m • 1 change
Want to know about travelling from Chicago to Missouri Botanical Garden? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Chicago to Missouri Botanical Garden. However, there are services departing from Chicago station and arriving at Missouri Botanical Garden station via St Louis Bus Station station. The journey, including transfers, takes approximately 9h 39m.
Chicago to Missouri Botanical Garden bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago to Missouri Botanical Garden bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
The distance between Chicago and Missouri Botanical Garden is 426 km. The road distance is 522 km.
Jefferson Lines operates a bus from Chicago Bus Station to St Louis Bus Station 3 times a day. Tickets cost $75–110 and the journey takes 5h 55m. Flixbus USA also services this route twice daily.