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Chicago to Port Saint Lucie buses

Find Transport to Port Saint Lucie

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Trip Overview

The average bus between Chicago and Port Saint Lucie takes 30h and the fastest bus takes 28h 15m. The bus runs, on average, 6 times per week from Chicago to Port Saint Lucie. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

30h
Duration
1,295 mi
Distance
$267
Average price
6 times a week
Frequency

Chicago to Port Saint Lucie bus times

Buses run 6 times a week between Chicago and Port Saint Lucie. The service departs Chicago at 6:10 AM in the morning, which arrives into Port Saint Lucie at 11:52:00. All services require a transfer at Atlanta Bus Station and take an average of 30h. The schedules shown below are for the next available departures.

Departing Tuesday, November 3, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAArea Regional Transit St Lucie28h 42m • 2 changes

Departing Wednesday, November 4, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAArea Regional Transit St Lucie28h 42m • 2 changes

Departing Thursday, November 5, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAArea Regional Transit St Lucie28h 42m • 2 changes

Departing Friday, November 6, 2026

  •  → 

    Arrives next day

    Greyhound USAFlixbus USAArea Regional Transit St Lucie28h 15m • 2 changes

Frequently asked questions

Want to know about travelling from Chicago to Port Saint Lucie? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Chicago to Port Saint Lucie.ExpandLaunch map view
  • Distance: 1,294.9 mi
  • Duration: 30h

What companies run services between Chicago, IL, USA and Port Saint Lucie, FL, USA?

You can take a bus from Chicago Bus Station to SW PSL Blvd & SE Bayshore Blvd via Atlanta Bus Station and SW Gatlin Blvd & SW Brescia St in around 29h 24m.

Operators