The average bus between Chicago and San Diego takes 2d 17h and the fastest bus takes 2d 14h. The bus runs, on average, 5 times per week from Chicago to San Diego. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 5 times a week between Chicago and San Diego. The earliest departure is at 5:15 PM in the evening, and the last departure from Chicago is at 5:15 PM which arrives into San Diego at 5:35 AM. All services require a transfer at St Louis Bus Station and take an average of 2d 17h. The schedules shown below are for the next available departures.
Want to know about travelling from Chicago to San Diego? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Chicago to San Diego. However, there are services departing from Chicago station and arriving at San Diego station via St Louis Bus Station station. The journey, including transfers, takes approximately 2d 17h.
Chicago to San Diego bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago to San Diego bus services, operated by Flixbus USA, arrive at San Diego station.
Book your Chicago to San Diego bus tickets online with Flixbus USA, Greyhound USA and Amtrak.
The distance between Chicago and San Diego is 2,786.9 km. The road distance is 3,781 km.
You can take a bus from Chicago Bus Station to San Diego via St Louis Bus Station, Los Angeles Union Station, and Los Angeles in around 2d 3h.