The average bus between Chicago and South Yarmouth takes 30h 28m and the fastest bus takes 24h 25m. The bus service runs several times per day from Chicago to South Yarmouth. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Chicago and South Yarmouth. The earliest departure is at 7:00 AM in the morning, and the last departure from Chicago is at 11:15 PM which arrives into South Yarmouth at 8:50 AM. All services require a transfer at New York Midtown and take an average of 30h 28m. The schedules shown below are for the next available departures.
Arrives +2 days



35h 35m • 3 changes
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25h 25m • 3 changes
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35h 35m • 3 changes
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Arrives next day



25h 25m • 3 changes
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35h 35m • 3 changes
Arrives +2 days
Want to know about travelling from Chicago to South Yarmouth? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Chicago to South Yarmouth. However, there are services departing from Chicago station and arriving at South Yarmouth station via New York Midtown. The journey, including transfers, takes approximately 30h 28m.
Chicago to South Yarmouth bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago to South Yarmouth bus services, operated by Flixbus USA, arrive at Hyannis Transportation Center station.
The distance between Chicago and South Yarmouth is 1,444.2 km. The road distance is 1,903 km.
You can take a bus from Chicago Bus Station to Main Street, South Yarmouth via New York Midtown, Boston, South Station Transp. Ctr, and Hyannis Transportation Center in around 25h 33m.