The average bus between Chicago and Washington University in St. Louis takes 7h 33m and the fastest bus takes 7h 12m. The bus service runs several times per day from Chicago to Washington University in St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run 3 times a day between Chicago and Washington University in St. Louis. The earliest departure is at 12:15 AM at night, and the last departure from Chicago is at 5:05 PM which arrives into Washington University in St. Louis at 12:53 AM. All services require a transfer at St Louis Bus Station and take an average of 7h 33m. The schedules shown below are for the next available departures.

7h 40m • 1 change

7h 13m • 1 change
Arrives next day

7h 48m • 1 change

7h 40m • 1 change

7h 13m • 1 change
Arrives next day

7h 48m • 1 change

7h 40m • 1 change

7h 13m • 1 change
Arrives next day

7h 48m • 1 change

7h 40m • 1 change

7h 13m • 1 change
Arrives next day

7h 48m • 1 change
Want to know about travelling from Chicago to Washington University in St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Chicago to Washington University in St. Louis. However, there are services departing from Chicago station and arriving at Washington University in St. Louis station via St Louis Bus Station station. The journey, including transfers, takes approximately 7h 33m.
Chicago to Washington University in St. Louis bus services, operated by Flixbus USA, depart from Chicago Bus Station.
Chicago to Washington University in St. Louis bus services, operated by Flixbus USA, arrive at St Louis Bus Station.
The distance between Chicago and Washington University in St. Louis is 424.7 km. The road distance is 524 km.
Flixbus USA operates a bus from Chicago Bus Station to St Louis Bus Station twice daily. Tickets cost $50–90 and the journey takes 5h 55m.