The average bus between Colma and Santa Clara takes 3h 14m and the fastest bus takes 2h 20m. The bus runs at least 3 times per hour from Colma to Santa Clara. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run every 20 minutes between Colma and Santa Clara. The earliest departure is at 12:26 AM at night, and the last departure from Colma is at 8:11 PM which arrives into Santa Clara at 10:59 PM. All services require a transfer, and take on average 3h 14m. The schedules shown below are for the next available departures.

4h 44m • 1 change

2h 21m • 1 change

2h 46m • 1 change

2h 40m • 1 change
Want to know about travelling from Colma to Santa Clara? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Colma to Santa Clara. However, there are services departing from Colma station and arriving at Santa Clara station via Palo Alto Transit Ctr-Bay 1. The journey, including transfers, takes approximately 3h 14m.
Colma to Santa Clara bus services, operated by SamTrans, depart from El Camino Real & Serramonte Blvd station.
Colma to Santa Clara bus services, operated by SamTrans, arrive at El Camino & Scott station.
The distance between Colma and Santa Clara is 57.1 km. The road distance is 63 km.
You can take a bus from El Camino Real & Serramonte Blvd to El Camino & Scott via Palo Alto Transit Center in around 3h 10m.