The average bus between Columbus and Des Moines takes 24h 45m and the fastest bus takes 20h 15m. The bus service runs several times per day from Columbus to Des Moines. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Columbus and Des Moines. The earliest departure is at 11:00 AM in the morning, and the last departure from Columbus is at 11:30 PM which arrives into Des Moines at 6:55 PM. All services require a transfer, and take on average 24h 45m. The schedules shown below are for the next available departures.
Arrives next day

27h 35m • 1 change
Arrives next day

19h 15m • 1 change
Arrives next day

27h 35m • 1 change
Arrives next day

19h 15m • 1 change
Arrives next day

27h 35m • 1 change
Arrives next day

19h 15m • 1 change
Arrives next day

27h 35m • 1 change
Arrives next day

19h 15m • 1 change
Want to know about travelling from Columbus to Des Moines? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Columbus to Des Moines. However, there are services departing from Columbus station and arriving at Des Moines station via Chicago Bus Station station. The journey, including transfers, takes approximately 24h 45m.
Columbus to Des Moines bus services, operated by Flixbus USA, depart from Columbus station.
Columbus to Des Moines bus services, operated by Flixbus USA, arrive at Des Moines station.
Book your Columbus to Des Moines bus tickets online with Flixbus USA and Greyhound USA.
The distance between Columbus and Des Moines is 911.1 km. The road distance is 1,123 km.
You can take a bus from Columbus to Des Moines via Chicago Bus Station in around 15h.