The average bus between Como and Brindisi takes 23h 35m and the fastest bus takes 21h 45m. The bus service runs several times per day from Como to Brindisi. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.
Buses run twice daily between Como and Brindisi. The earliest departure is at 12:05 PM in the afternoon, and the last departure from Como is at 8:20 PM which arrives into Brindisi at 10:25 PM. All services require a transfer, and take on average 23h 35m. The schedules shown below are for the next available departures.
Arrives next day

23h 45m • 1 change
Arrives next day

26h 5m • 1 change
Arrives next day

23h 45m • 1 change
Arrives next day

26h 5m • 1 change
Want to know about travelling from Como to Brindisi? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.
No, there is no direct bus from Como to Brindisi. However, there are services departing from Como station and arriving at Brindisi station via Milan. The journey, including transfers, takes approximately 23h 35m.
Como to Brindisi bus services, operated by FlixBus, depart from Como station.
Como to Brindisi bus services, operated by FlixBus, arrive at Brindisi station.
Book your Como to Brindisi bus tickets online with FlixBus.
The distance between Como and Brindisi is 918.7 km. The road distance is 1,064 km.
You can take a bus from Como to Brindisi via Milano, Autostazione Lampugnano in around 15h 25m.