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Costa Mesa to St. Louis buses

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Trip Overview

The bus between Costa Mesa and St. Louis takes 44h 17m. The bus runs, on average, 5 times per week from Costa Mesa to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

44h 17m
Duration
1,938 mi
Distance
$355
Average price
5 times a week
Frequency

Costa Mesa to St. Louis bus times

Buses run 5 times a week between Costa Mesa and St. Louis. The earliest departure is at 8:48 AM in the morning, and the last departure from Costa Mesa is at 8:48 AM which arrives into St. Louis at 7:05 AM. All services require a transfer at Harbor-East Shuttle Area and take an average of 44h 17m. The schedules shown below are for the next available departures.

Departing Monday, October 12, 2026

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    Arrives +2 days

    OCTAMetro Los AngelesMetro Los AngelesGreyhound USA44h 17m • 3 changes

Departing Tuesday, October 13, 2026

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    Arrives +2 days

    OCTAMetro Los AngelesMetro Los AngelesGreyhound USA44h 17m • 3 changes

Departing Wednesday, October 14, 2026

  •  → 

    Arrives +2 days

    OCTAMetro Los AngelesMetro Los AngelesGreyhound USA44h 17m • 3 changes

Departing Thursday, October 15, 2026

  •  → 

    Arrives +2 days

    OCTAMetro Los AngelesMetro Los AngelesGreyhound USA44h 17m • 3 changes

Departing Friday, October 16, 2026

  •  → 

    Arrives +2 days

    OCTAMetro Los AngelesMetro Los AngelesGreyhound USA44h 17m • 3 changes

Frequently asked questions

Want to know about travelling from Costa Mesa to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Costa Mesa to St. Louis.ExpandLaunch map view
  • Distance: 1,938.3 mi
  • Duration: 44h 17m

What companies run services between Costa Mesa, CA, USA and St. Louis, MO, USA?

Greyhound USA operates a bus from El Monte Bus Stop to St Louis Bus Station once daily. Tickets cost $290–470 and the journey takes 39h 40m.

Operators