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DeSoto to St. Louis buses

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Trip Overview

The bus between DeSoto and St. Louis takes 16h 20m. The bus runs, on average, 2 times per week from DeSoto to St. Louis. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

16h 20m
Duration
730 mi
Distance
$136
Average price
Twice a week
Frequency

DeSoto to St. Louis bus times

Buses run twice a week between DeSoto and St. Louis. The earliest departure is at 2:45 PM in the afternoon, and the last departure from DeSoto is at 2:45 PM which arrives into St. Louis at 7:05 AM. All services require a transfer at Southwest Medical District/Parkland and take an average of 16h 20m. The schedules shown below are for the next available departures.

Departing Monday, October 12, 2026

  •  → 

    Arrives next day

    Dallas Area Rapid Transit (DART)Dallas Area Rapid Transit (DART)Flixbus USAGreyhound USA16h 20m • 3 changes

Departing Thursday, October 15, 2026

  •  → 

    Arrives next day

    Dallas Area Rapid Transit (DART)Dallas Area Rapid Transit (DART)Flixbus USAGreyhound USA16h 20m • 3 changes

Frequently asked questions

Want to know about travelling from DeSoto to St. Louis? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from DeSoto to St. Louis.ExpandLaunch map view
  • Distance: 729.6 mi
  • Duration: 16h 20m

What companies run services between DeSoto, TX, USA and St. Louis, MO, USA?

You can take a bus from Glenn Heights P & R to St Louis Bus Station via Southwest Medical District/Parkland, Gaston @ Good Latimer - N - Ns, Downtown Dallas / Deep Ellum, and Oklahoma City Bus Station in around 16h 50m.

Operators