Rome2Rio

Des Moines to Florence buses

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Trip Overview

The bus between Des Moines and Florence takes 2d 4h. The bus runs, on average, 5 times per week from Des Moines to Florence. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 4h
Duration
1,297 mi
Distance
$274
Average price
5 times a week
Frequency

Des Moines to Florence bus times

Buses run 5 times a week between Des Moines and Florence. The service departs Des Moines at 7:50 AM in the morning, which arrives into Florence at 13:30:00. All services require a transfer at Indianapolis Union Station and take an average of 2d 4h. The schedules shown below are for the next available departures.

Departing Tuesday, November 10, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA2d 4h • 2 changes

Departing Wednesday, November 11, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA2d 4h • 2 changes

Departing Thursday, November 12, 2026

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    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA2d 4h • 2 changes

Departing Friday, November 13, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA2d 4h • 2 changes

Departing Saturday, November 14, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAGreyhound USA2d 4h • 2 changes

Frequently asked questions

Want to know about travelling from Des Moines to Florence? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Florence.ExpandLaunch map view
  • Distance: 1,297.5 mi
  • Duration: 2d 4h

What companies run services between Des Moines, IA, USA and Florence, SC, USA?

You can take a bus from Des Moines to Florence Bus Station via Indianapolis Union Station and Atlanta Bus Station in around 29h 10m.

Operators