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Des Moines to Fort Myers buses

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Trip Overview

The bus between Des Moines and Fort Myers takes 2d 7h. The bus runs, on average, 3 times per week from Des Moines to Fort Myers. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

2d 7h
Duration
1,647 mi
Distance
$330
Average price
3 times a week
Frequency

Des Moines to Fort Myers bus times

Buses run 3 times a week between Des Moines and Fort Myers. The service departs Des Moines at 7:50 AM in the morning, which arrives into Fort Myers at 16:35:00. All services require a transfer at Indianapolis Union Station and take an average of 2d 7h. The schedules shown below are for the next available departures.

Departing Tuesday, November 17, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USAFlixbus USA2d 7h • 3 changes

Departing Wednesday, November 18, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USAFlixbus USA2d 7h • 3 changes

Departing Thursday, November 19, 2026

  •  → 

    Arrives +2 days

    Greyhound USAGreyhound USAFlixbus USAFlixbus USA2d 7h • 3 changes

Frequently asked questions

Want to know about travelling from Des Moines to Fort Myers? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Fort Myers.ExpandLaunch map view
  • Distance: 1,646.7 mi
  • Duration: 2d 7h

What companies run services between Des Moines, IA, USA and Fort Myers, FL, USA?

You can take a bus from Des Moines to Fort Myers Bus Stop via Indianapolis Union Station, Atlanta Bus Station, and Tampa Bus Station in around 35h 40m.

Operators