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Des Moines to Gainesville buses

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Trip Overview

The average bus between Des Moines and Gainesville takes 34h 15m and the fastest bus takes 34h 5m. The bus runs, on average, 6 times per week from Des Moines to Gainesville. The journey time may be longer on weekends and holidays; use the search form on this page to search for a specific travel date.

34h 15m
Duration
1,327 mi
Distance
$268
Average price
6 times a week
Frequency

Des Moines to Gainesville bus times

Buses run 6 times a week between Des Moines and Gainesville. The service departs Des Moines at 7:50 AM in the morning, which arrives into Gainesville at 18:55:00. All services require a transfer at Indianapolis Union Station and take an average of 34h 15m. The schedules shown below are for the next available departures.

Departing Saturday, October 31, 2026

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    Arrives next day

    Greyhound USAGreyhound USAFlixbus USA35h 5m • 2 changes

Departing Sunday, November 1, 2026

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    Arrives next day

    Greyhound USAGreyhound USAFlixbus USA34h 5m • 2 changes

Departing Monday, November 2, 2026

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    Arrives next day

    Greyhound USAGreyhound USAFlixbus USA34h 5m • 2 changes

Departing Tuesday, November 3, 2026

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    Arrives next day

    Greyhound USAGreyhound USAFlixbus USA34h 5m • 2 changes

Departing Wednesday, November 4, 2026

  •  → 

    Arrives next day

    Greyhound USAGreyhound USAFlixbus USA34h 5m • 2 changes

Frequently asked questions

Want to know about travelling from Des Moines to Gainesville? We have put together a list of the most frequently asked questions from our users such as: What is the cheapest mode of transport? What is the quickest option? How much do tickets usually cost? and many more.

Map of how to get from Des Moines to Gainesville.ExpandLaunch map view
  • Distance: 1,327.5 mi
  • Duration: 34h 15m

What companies run services between Des Moines, IA, USA and Gainesville, FL, USA?

You can take a bus from Des Moines to Gainesville via Indianapolis Union Station and Atlanta Bus Station in around 28h.

Operators